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Journal of Veterinary Diagnostic Investigation, Vol 15, Issue 5, 457-460
Copyright © 2003 by American Association of Veterinary Laboratory Diagnosticians

Case Reports

Neuronal ceroid-lipofuscinosis in a Labrador Retriever

JH Rossmeisl Jr, R Duncan, J Fox, ES Herring, and KD Inzana

Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

An 8-year-old Labrador Retriever with an 11-month history of progressive partial seizures and necropsy examination findings characteristic of the lamellar form of canine neuronal ceroid-lipofuscinosis (NCL) is presented. The clinical, light microscopic, and ultrastructural features of this case most closely resemble human adult-onset NCL (Kufs disease). This is the first report of NCL occurring in the Labrador Retriever breed.


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C.-H. Tang, J.-W. Lee, M. G. Galvez, L. Robillard, S. E. Mole, and H. A. Chapman
Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological Disease
Mol. Cell. Biol., March 15, 2006; 26(6): 2309 - 2316.
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