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Journal of Veterinary Diagnostic Investigation Vol. 19 Issue 2, 205-208
Copyright © 2007 by the American Association of Veterinary Laboratory Diagnosticians
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Brief Communications

Vertebral polyostotic lymphoma in a young dog

Vascellari Marta1, Silvia Tasca, Tommaso Furlanello, Erika Carli, Carlo Patron, Franco Mutinelli and Marco Caldin

Correspondence: 1Vascellari Marta, Histopathology Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020 Legnaro (PD), Italy, e-mail: mvascellari{at}izsvenezie.it

An unusual clinical presentation of lymphoma with vertebral involvement in a dog is reported. A 20-month-old intact female Golden Retriever presented with progressive paraparesis and anorexia. Complete blood count and serum biochemistry profile demonstrated pancytopenia and hypercalcemia. Ventral fusion of the lumbar vertebrae by new bony tissue deposition was evident on X-ray and CT scan. Fine needle aspiration revealed neoplastic lymphoid cells in lymph nodes and bone marrow. Histologically, vertebral bone and osteophytes, liver, bone marrow, kidney, and lymph nodes were diffusely infiltrated by neoplastic, lymphoid cells, with scant cytoplasm and round hyperchromatic nuclei. Polyostotic and medullary T-cell lymphoma with spondylosis was diagnosed. Lymphoma mainly affecting bone is uncommon in the dog. The present case differs from previously described polyostotic lymphomas in clinical signs of the disease, mainly attributable to spondylarthrosis. In addition, lymphomatous proliferation was associated with osteoproductive lesions of the vertebrae.

Key Words: Dog • flow cytometry • histopathology • polyostotic lymphoma • spondylosis




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D. G. Rogers and V. A. Aliano
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J Vet Diagn Invest, May 1, 2009; 21(3): 390 - 394.
[Abstract] [Full Text] [PDF]


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