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Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 3, 289-296
Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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Full Scientific Reports

Histopathologic and immunohistochemical findings in two white-tailed deer fawns persistently infected with Bovine viral diarrhea virus

Colleen Duncan1, Julia Ridpath, Mitchell V. Palmer, Elizabeth Driskell and Terry Spraker

Correspondence: 1Corresponding Author: Colleen Duncan, Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake, Fort Collins, CO 80523, e-mail: colleen.duncan{at}colostate.edu

Bovine viral diarrhea virus (BVDV) is an important pathogen of domestic cattle. Serologic, experimental, and individual case studies explored the presence and pathogenesis of the virus in wild ungulates; however, there remain large gaps in knowledge regarding BVDV infection in nonbovine species. Live twins were born from a white-tailed deer (Odocoileus virginianus) doe infected with noncytopathic BVDV during its first trimester of pregnancy. The twins died at 1 day of age from trauma unrelated to the infection, and tissues were collected for histologic and immunohistochemical examination. The most significant histologic abnormality was diffuse depletion of B-lymphocytes in both fawns. The BVDV antigen was distributed widely throughout many tissues and cell types, most notably epithelium and vascular endothelium, consistent with that reported in cattle. In contrast to cattle, lymphocytes exhibited only very rare positive staining.

Key Words: Bovine viral diarrhea virus • Odocoileus virginianus • persistent infection • white-tailed deer




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D. D. Nelson, M. J. Dark, D. S. Bradway, J. F. Ridpath, N. Call, J. Haruna, F. R. Rurangirwa, and J. F. Evermann
Evidence for persistent Bovine viral diarrhea virus infection in a captive mountain goat (Oreamnos americanus)
J Vet Diagn Invest, November 1, 2008; 20(6): 752 - 759.
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