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Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 6, 824-826
Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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Case Reports

Presumed primary muscular lymphoma in a dog

Céline Thuilliez1, Dorothée Watrelot-Virieux, Franck Chanut, Corinne Fournel-Fleury, Frédérique Ponce and Thierry Marchal

Correspondence: 1Corresponding Author: Céline Thuilliez, Department of Pathology, Veterinary School of Lyon, 1 Avenue Bourgelat, 69280 Marcy l'Etoile, France. celinethuilliez{at}yahoo.fr

A case of presumed primary muscular lymphoma in an 8-year-old, intact, male Newfoundland dog is reported. The dog was presented for evaluation of an infiltrating ventral cervical mass, respiratory distress, and anorexia of 1-month duration. Fine-needle aspiration of the mass revealed anaplastic large cell lymphoma. Despite chemotherapy, health status declined and the animal was euthanized a few weeks later. At necropsy, the mass infiltrated the cervical muscles and extended ventrally to the left forelimb and cranially to the tongue and laryngeal musculature. Other muscles were infiltrated by the same neoplasm (diaphragm and intercostal, abdominal, and gluteal muscles) indicating a probable multicentric origin. Histological examination confirmed the diagnosis of anaplastic large cell lymphoma, which showed a strong muscular tropism. Immunohistochemical staining revealed neoplastic cell reactivity for cluster of differentiation 3 (CD3) and Ki-67 antigens (70% and 90%, respectively). The neoplastic cells were negative for CD79a. The presumed histological diagnosis in this dog was primary muscular anaplastic large T-cell lymphoma.

Key Words: CD3 • CD79a • dogs • immunohistochemistry • Ki-67 • lymphoma • skeletal muscles






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