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Malignant acoustic schwannoma in a dog

Correspondence: ¹Corresponding Author: Therese Ottinger, Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden. therese.ottinger{at}bvf.slu.se

A malignant schwannoma of the right acoustic nerve of a dog is described. The neoplasm was found during necropsy of a 12-year-old, spayed, female Labrador Retriever that experienced a sudden onset of severe pain in the neck and upon opening the mouth. Concurrent mild hind limb ataxia also was present. The tumor had infiltrative growth, and the spindle-shaped neoplastic cells were arranged in sheets and concentric whorls. Immunohistochemical staining of the neoplastic spindle cells was positive for S-100 antigen, neuron-specific enolase, and glial fibrillary acidic protein.

Key Words: Acoustic nerve • dogs • glial fibrillary acidic protein • Labrador Retriever • malignant schwannoma • neuron-specific enolase • S-100