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Generalized tularemia in a vervet monkey (Chlorocebus aethiops) and a patas monkey (Erythrocebus patas) in a zoo

Miklós Gyuranecz¹, László Fodor, László Makrai, István Szke, Katalin Jánosi, Katalin Krisztalovics and Károly Erdélyi

Correspondence: ¹Corresponding Author: Miklós Gyuranecz, Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Hungária krt. 23–25, H-1143 Budapest, Hungary. Gyuranecz.Miklos{at}aotk.szie.hu

Generalized tularemia was diagnosed in a vervet monkey (Chlorocebus aethiops) and a patas monkey (Erythrocebus patas), both of which died suddenly in the Szeged Zoo, Szeged, Hungary. Macroscopic lesions in each animal included disseminated, grayish-white foci in the lungs, lymph nodes, spleen, liver, and kidney. All focal lesions were characterized microscopically as purulent to pyogranulomatous to granulomatous inflammation with necrosis. Francisella tularensis subsp. holarctica strains were isolated from tissue samples on modified Francis agar after mouse passage and identified by a commercial carbon-source utilization test and polymerase chain reaction–based amplification and sequencing of a portion of the 16S ribosomal RNA gene.

Key Words: Francisella tularensis subspecies holarctica • polymerase chain reaction • primates • tularemia • zoonosis