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Journal of Veterinary Diagnostic Investigation Vol. 21 Issue 4, 535-539
Copyright © 2009 by the American Association of Veterinary Laboratory Diagnosticians
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Case Reports

Clinical, histologic, and immunohistochemical features of an undifferentiated renal tubular carcinoma in a juvenile olive baboon (Papio anubis)

Nuria García, Guillermo Ramis1, Francisco J. Pallarés, Juan I. Seva, Carlos M. Martínez, Juan J. Quereda and Antonio Muñoz

Correspondence: 1Corresponding Author: Guillermo Ramis, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30.071 Murcia, Spain. guiramis{at}um.es

An undifferentiated renal tubular carcinoma was diagnosed in a juvenile male olive baboon (Papio anubis). The animal suddenly appeared depressed and refused to eat. During physical examination, a firm, palpable mass in the left abdominal area and flank pain were detected. Clinical pathology findings included mild anemia, hypoalbuminemia, hyponatremia, and mildly increased serum creatinine and urea concentrations. Radiographs revealed a large mass in the left abdominal area. Exploratory laparotomy disclosed a 10 cm x 15 cm multilobulated mass involving the left kidney and adjacent organs. Because of a poor prognosis, the animal was humanely euthanized, and necropsy was performed. Tissue samples of the neoplasm were taken for histopathological examination. Immunohistochemical staining was done using vimentin, cytokeratin, S-100 protein, Ki-67, {alpha}-actin, and desmin-specific primary antibodies. Microscopically, elongated and irregular tubules were lined by 2 or more layers of atypical epithelial cells. Anisocytosis, anisokaryosis, and frequent mitotic figures were also observed. Following immunohistochemical staining, the cytoplasm of neoplastic cells was positive for cytokeratin, vimentin, and S-100 protein and negative for {alpha}-actin and desmin. Positive nuclear staining for Ki-67 was observed. The neoplasm was diagnosed as an undifferentiated renal tubular carcinoma.

Key Words: Baboons • immunohistochemistry • juvenile • primate • renal carcinoma






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