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Journal of Veterinary Diagnostic Investigation Vol. 21 Issue 5, 715-719
Copyright © 2009 by the American Association of Veterinary Laboratory Diagnosticians
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Case Reports

Gastric B-cell lymphoma with Mott cell differentiation in a dog

Gabrita De Zan1, Valentina Zappulli, Laura Cavicchioli, Linda Di Martino, Eriberta Ros, Giorgia Conforto and Massimo Castagnaro

Correspondence: 1Corresponding Author: De Zan Gabrita, Dipartimento di Sanità Pubblica, Patologia Comparata ed Igiene Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Padova, Agripolis, Viale dell'Università, 16, 35020 Legnaro, Padova, Italy. gabrita.dezan{at}unipd.it

A gastric lymphoid tumor with involvement of regional lymph nodes and spleen was diagnosed in an 8-year-old crossbreed male dog with a 6-month history of gastrointestinal disease. Despite surgical excision and palliative therapy (prednisolone and cimetidine), the dog was euthanatized due to worsening of clinical signs. At necropsy, multiple white, solid, nodular, infiltrative masses were observed in the stomach, duodenum, spleen, liver, and lungs in association with generalized lymph node enlargement. Cytology, histology, histochemistry, immunohistochemistry, and electron microscopy revealed that the neoplastic cell population was composed of B lymphocytes that contained variable amounts of round periodic acid–Schiff-positive cytoplasmic globules consistent with Russell bodies. The tumor most likely represented a variant of B-cell neoplasia with extensive Mott cell differentiation.

Key Words: B-cell lymphoma • dogs • electron microscopy • immunohistochemistry • Mott cell






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