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A KIT-positive gastrointestinal stromal tumor in a ferret (Mustela putorius furo)

Correspondence: ¹Corresponding Author: Florence Bernex, Unité d'Embryologie, d'Histologie et d'Anatomie Pathologique and INRA UMR 955, Ecole Nationale Vétérinaire d'Alfort, 7 avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex, France. fbernex{at}vet-alfort.fr

A 1.5-year-old, neutered, male ferret (Mustela putorius furo) was presented with sudden lethargy, anorexia, and diarrhea. Clinical and radiographic examinations revealed an intra-abdominal mass. An explorative laparotomy was performed. A neoplasm, located in the ileum wall, was submitted for histopathologic examination. The tumor consisted of weakly eosinophilic spindle cells arranged in a compact pattern with haphazardly interlacing bundles. Neoplastic cells labeled positively for KIT (cluster of differentiation 117, stem cell factor receptor) and vimentin. Based on histologic and immunohistologic results, this tumor was diagnosed as a gastrointestinal stromal tumor. Results suggest that this ferret tumor shares strong similarities with the canine and human counterparts.

Key Words: Digestive tract • ferrets • gastrointestinal stromal tumor • ileum • immunohistochemistry • KIT • Mustela putorius furo • tumor